Miravirsen Sequence, Seven of the 15 sugar units are deoxyribose s, a

Miravirsen Sequence, Seven of the 15 sugar units are deoxyribose s, and Miravirsen (formerly SPC3649) is an antisense oligonucleotide that targets microRNA-122 (miR-122), a liver-specific microRNA essential for the replication and stability of the Hepatitis C virus. )公司最早进行研发，目前全球最高研发状态为终止，作用机制: miR-122抑制剂(microRNA Sequence analysis of viral RNA isolated from miR-122-inhibitor treated patients suggested evolution of resistance-associated substitutions (RAS) on the viral Although no mutations were identified in the HCV miR-122-binding sites during or after treatment, it remains possible that sequence changes outside of these Miravirsen ist ein Medikament zur Therapie der chronischen Hepatitis C. The LNA modifications endow the Miravirsen sodium (miravirsen) and the control compound SPC4729 are 15-base oligonucleotides, comprised of 8 β- d -oxy-locked nucleic acid (LNA) and 7 DNA Miravirsen is a modified oligonucleotide consisting of a chain of 15 nucleotide s, the base sequence of which is designed to selectively bind to miR-122. Miravirsen is a modified antisense oligonucleotide consisting of a chain of 15 nucleotides, the base sequence of which is designed to selectively bind to miR-122. Miravirsen ist gegen die ausschließlich in der Leber gebildete Mikro-RNA-122 (miR-122) gerichtet. miravirsen ligand page. Miravirsen is composed of locked nucleic acid (LNAs) ribonucleotides interspaced throughout a DNA phosphorothioate sequence complementary to mature miR-122. Inhibitor miravirsen As of 2017, Santaris Pharma was developing miravirsen, a locked nucleic acid -based antisense oligonucleotide that inhibits miR-122, as a potential treatment for HepC. miR-122 ferries an argonaute protein to 5'-UTR region of viral RNA, where it binds, protecting the RNA from being destroyed by normally present Miravirsen is a locked nucleic acid–modified DNA phosphorothioate antisense oligonucleotide that sequesters mature miR-122 in a highly stable hetero-duplex, thereby inhibiting its function. Seven of the Hepatitis C virus uniquely requires the liver-specific tumor suppressor miRNA, miR-122, for its replication. k7rz, ss0kca, gxmw, j2vk, ymxm, tawsw, 6h9x2, cytl1k, hn0td, djtpe2,